NEET 2009 Biology question

The genetic defect - adenosine deaminase (ADA) deficiency may be cured permanently by:

(1)administering adenosine deaminase activators.
(2)introducing bone marrow cells producing ADA into cells at early embryonic stages.Correct
(3)enzyme replacement therapy.
(4)periodic infusion of genetically engineered lymphocytes having functional ADA cDNA.

Answer: (2)

Solution

ADA deficiency (a cause of severe combined immunodeficiency, SCID) is treated by enzyme replacement therapy or by infusing genetically engineered lymphocytes, but these are not permanent cures because the lymphocytes are short-lived and the infusions

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Question ID VK-090209