NEET 2010 Biology question

Toxic agents present in food which interfere with thyroxine synthesis lead to the development of

(1)cretinism
(2)simple goitreCorrect
(3)thyrotoxicosis
(4)toxic goitre

Answer: (2)

Solution

Goitrogens (toxic substances in food, e.g. in cabbage and cassava) block thyroxine synthesis. Low thyroxine removes the negative feedback on the pituitary, so TSH rises continuously and over-stimulates the thyroid, enlarging it: simple (endemic) goitre, option (2). The

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Question ID VK-090579