NEET 2017 Biology question
Anaphase promoting complex (APC) is a protein degradation machinery necessary for proper mitosis of animal cells. If APC is defective in a human cell, which of the following is expected to occur?
Answer: (3)
Solution
The anaphase promoting complex is a ubiquitin ligase that targets securin (and cyclin B) for degradation. Degradation of securin activates separase, which cleaves cohesin and allows sister chromatids to separate in anaphase. If APC is defective, cohesion is not
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