NEET 2017 Biology question

Thalassemia and sickle cell anemia are caused due to a problem in globin molecule synthesis. Select the correct statement.

(1)Both are due to a qualitative defect in globin chain synthesis
(2)Both are due to a quantitative defect in globin chain synthesis
(3)Thalassemia is due to less synthesis of globin moleculesCorrect
(4)Sickle cell anemia is due to a quantitative problem of globin molecules

Answer: (3)

Solution

Thalassemia is a quantitative problem: mutation or deletion of globin genes causes reduced (too few) synthesis of the or globin chains of haemoglobin. Sickle cell anaemia is a qualitative problem: a single base substitution (GAG to GUG)

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Question ID VK-092193