NEET Biology question

Not in NEET syllabus

What does the following reaction show? α-ketoglutaric acid + NH4+ + NADPH --(glutamate dehydrogenase)--> Glutamate + H2O + NADP+ Choose the correct option.

(A)Oxidative deamination
(B)Reductive aminationCorrect
(C)Transamination
(D)Deamination

Answer: (B)

Solution

Per NCERT Class 11 (Section 12.6.2, *Fate of Ammonia*), the direct incorporation of ammonium ion (NH4+) into α-ketoglutaric acid, using a reduced coenzyme (NADPH) and catalysed by glutamate dehydrogenase, to form glutamate is called reductive amination.

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Question ID VK-112923