NEET Biology question

Sickle cell anaemia is

(A)An autosomal linked dominant trait
(B)Caused by substitution of glutamic acid by valine in the β-globin chain of haemoglobinCorrect
(C)Caused by a change in base pair of DNA
(D)Characterized by elongated sickle like RBCs with a nucleus

Answer: (B)

Solution

Sickle cell anaemia results from a single point mutation in the beta-globin gene that replaces the normal glutamic acid at the sixth position of the β-chain with valine, matching the corrected option (b); the disease is actually autosomal recessive, not dominant (ruling out (a)); while

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Question ID VK-119616