NEET Biology question
Match the human genetic disorder in column I with the causative abnormal chromosome in column II.
| Column I | Column II | |---|---| | (A) Sickle-cell anaemia | (1) Sex-linked (X-chromosome) | | (B) Colour blindness | (2) Autosomal chromosome-7 | | (C) Phenylketonuria | (3) Autosomal chromosome-11 | | (D) Cystic fibrosis | (4) Autosomal chromosome-4 | | (E) Huntington's disease | (5) Autosomal chromosome-12 |
Solution
Sickle-cell anaemia is caused by a mutation in the β-globin gene on autosomal chromosome 11, matching A(3); colour blindness is caused by a recessive allele on the X chromosome, matching B(1); phenylketonuria results from a defective phenylalanine hydroxylase gene on autosomal
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