NEET Biology question

Thalassaemia and sickle-cell anaemia are caused due to a problem in globin molecule synthesis. Select the correct statement.

(A)Both are due to a quantitative defect in globin chain synthesis
(B)Thalassaemia is due to less synthesis of globin moleculesCorrect
(C)Sickle cell anaemia is due to a quantitative problem of globin molecules
(D)Both are due to a qualitative defect in globin chain synthesis

Answer: (B)

Solution

Sickle-cell anaemia is caused by a point mutation (GAG→GTG at codon 6 of the β-globin gene), producing a structurally altered (qualitatively defective) haemoglobin molecule, but in normal quantity. Thalassaemia, by contrast, results from mutations/deletions that reduce the *rate of synthesis* of one of the globin

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Question ID VK-120201