NEET Biology question

Biology Principles of Inheritance and Variation NEET

The disease sickle-cell anaemia is caused by the substitution of (i) by (ii) at the (iii) position of the (iv) globin chain of the haemoglobin molecule. Which of the following correctly fills the blanks?

(A)(i) Valine, (ii) glutamic acid, (iii) sixth, (iv) beta
(B)(i) Glutamic acid, (ii) valine, (iii) sixth, (iv) betaCorrect
(C)(i) Glutamic acid, (ii) valine, (iii) fifth, (iv) beta
(D)(i) Valine, (ii) glutamic acid, (iii) fifth, (iv) beta

Answer: (B)

Solution

In sickle-cell anaemia, the point mutation causes the amino acid glutamic acid (the normal residue, substituted out, filling (i)) to be replaced by valine

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Question ID VK-120371