NEET Biology question
Statement 1 (Assertion): Sickle-cell anaemia is an autosome-linked recessive disorder that can be transmitted if both parents are heterozygous for the gene. Statement 2 (Reason): In sickle-cell anaemia, the haemoglobin molecule undergoes polymerization under low oxygen tension, causing a change in the shape of the RBC.
Answer: (B)
Solution
Sickle-cell anaemia is indeed an autosomal recessive disorder, requiring both parents to be at least heterozygous carriers for an affected child to be born (Statement 1 is true). Statement 2 correctly describes the molecular/physiological mechanism of the disease — haemoglobin-S polymerization under low oxygen
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