NEET Biology question

Not in NEET syllabus

Inbreeding for five generations led to production of homozygous transgenic mice. However, these homozygous males or females were infertile. Which of the following approaches is most preferable and economical to obtain heterozygous transgenic animals continuously?

(A)More transgenic founder (1st) animals should be generated
(B)Crossing (breeding) of transgenic mice with wild type mice in earlier generations should be done for continued production of transgenic heterozygous offspringCorrect
(C)Inbreeding should be avoided after the 5th generation
(D)Homozygous transgenic mice should be mated with heterozygous transgenic mice for continued production of transgenic heterozygous offspring

Answer: (B)

Solution

Crossing some of the transgenic mice with wild-type mice in the earlier generations by simple mating maintains a continuous,

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Question ID VK-124191