NEET Biology question

A bacterial cell was transformed with a recombinant DNA that was generated using a human gene. However, the transformed cells did not produce the desired protein. Reasons could be

(A)The human gene may have introns which bacteria cannot processCorrect
(B)Amino acid codons for humans and bacteria are different
(C)Human protein is formed but degraded by bacteria
(D)All of the above

Answer: (A)

Solution

The single most fundamental reason a bacterium fails to make a correct human protein from an unmodified human gene is that human genes are typically split by introns, while bacteria are prokaryotes that lack the nuclear spliceosomal machinery needed to remove introns from a pre-mRNA transcript — so a human gene

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Question ID VK-125297