NEET Biology question

The genetic defect — Adenosine Deaminase (ADA) deficiency — may be cured permanently by

(A)Periodic infusion of genetically engineered lymphocytes having functional ADA cDNA
(B)Administering adenosine deaminase activators
(C)Introducing the gene for ADA, isolated from bone marrow cells, into cells at an early embryonic stageCorrect
(D)Enzyme replacement therapy

Answer: (C)

Solution

Although periodic lymphocyte infusion and enzyme replacement therapy can manage ADA deficiency, neither is curative because the engineered lymphocytes or supplied enzyme are not permanent and must be repeatedly readministered, whereas

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Question ID VK-125458