NEET Biology question
Which of the following statements regarding the structure of proinsulin and mature insulin are not correct?
1. Proinsulin is made up of three polypeptide chains – A, B and C. 2. C-polypeptide chain with 33 amino acids is removed prior to insulin formation. 3. Mature insulin is made up of 51 amino acids arranged in two polypeptide chains – A and B. 4. Polypeptide chain A has 30 amino acids and polypeptide chain B has 21 amino acids. 5. Polypeptide chains A and B are interconnected by only one S – S linkage.
Solution
Statements 1–3 are correct (proinsulin folds as A-C-B, C-peptide of about 33 residues is removed, mature insulin has 51 residues in chains A and B), but statement 4 is reversed (chain A actually has 21
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