NEET Biology question

BiologyChemical Coordination and IntegrationNEET

Which of the following statements regarding the structure of proinsulin and mature insulin are not correct?

1. Proinsulin is made up of three polypeptide chains – A, B and C. 2. C-polypeptide chain with 33 amino acids is removed prior to insulin formation. 3. Mature insulin is made up of 51 amino acids arranged in two polypeptide chains – A and B. 4. Polypeptide chain A has 30 amino acids and polypeptide chain B has 21 amino acids. 5. Polypeptide chains A and B are interconnected by only one S – S linkage.

Answer: (C)

Solution

Statements 1–3 are correct (proinsulin folds as A-C-B, C-peptide of about 33 residues is removed, mature insulin has 51 residues in chains A and B), but statement 4 is reversed (chain A actually has 21

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Question ID VK-125774