NEET Biology question

What is the permanent cure of adenosine deaminase (ADA) deficiency in children?

(A)Bone marrow transplantation
(B)Enzyme replacement therapy in which functional ADA is given to patient by injection
(C)Infusion of genetically engineered lymphocytes (in which functional ADA – cDNA is introduced) into the patient's blood
(D)Introduction of gene isolated from bone marrow cells which produce ADA, into the cells of the patient at early embryonic stagesCorrect

Answer: (D)

Solution

As established, only introducing the isolated functional ADA gene at the early embryonic stage ensures it is present in all cells including germ cells,

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Question ID VK-125780