NEET Biology question

Select the correct bases of DNA, RNA and amino acid of beta chain resulting in sickle cell anaemia.

DNA | RNA | Amino Acid

(A)CTC/GAG, GAG, Glutamic acid
(B)CAC/GTG, GUG, ValineCorrect
(C)CAC/GTC, GAG, Valine
(D)CTC/GAG, GUG, Valine

Answer: (B)

Solution

Sickle cell anaemia results from a single base substitution in the sixth codon of the beta-globin gene: the mutant DNA duplex reads CAC (template strand) / GTG (coding strand), transcribed into the mRNA codon GUG, which is translated as valine — replacing the normal GAG (coding strand) / CTC (template) codon that

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Question ID VK-119571